The mechanism of the L-threo-3-methylaspartate ammonia-lyase reaction has been investigated using double isotope (2H/1H, 15N/14N) fractionation techniques; the physiological substrate is deaminated via a concerted mechanism in which Cβ–H and Cα–N bond cleavage occur in the same transition state.
N. P. Botting, A. A. Jackson and D. Gani, J. Chem. Soc., Chem. Commun., 1989, 1583 DOI: 10.1039/C39890001583
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