Synthesis of 1,11β-ethanoestra-1,3,5(10)-triene-3,17β-diol: a novel bridged steroid derivative
Abstract
The generation of an electrophilic centre on the 11β-(2-hydroxyethyl) estradiol 3,17β-bis(benzyl ether)(2) leads in two steps to the corresponding 1,11β-ethano-estradiol in a 61% overall yield.