Preference for anti 1,4-elimination of hydrochloric acid promoted by base in systems with non-cyclic C(1)–C(2) bonds
Abstract
Stereochemical studies of base promoted 1,4-elimination to transoid dienes from the designed diastereoisomers (1R*)-(1-2H1)-3-[(1R*)-1-chloroethyl]indene (1a) and (1R*)-(1-2H1)-3-[(1S*)-1-chloroethyl]-indene (1b) show that anti elimination is preferred.