A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.
N. Chida, Y. Furuno and S. Ogawa, J. Chem. Soc., Chem. Commun., 1989, 1230 DOI: 10.1039/C39890001230
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