Isolation of a new β-lactam-containing metabolite, from incubation of the three deuteriated tripeptides (1b–d) with isopencillin N synthase (IPNS) has provided evidence of an epoxide type intermediate; a unified mechanism is proposed for the formation of products by IPNS from unsaturated precursors.
J. E. Baldwin, R. M. Adlington, M. Bradley, N. J. Turner and A. R. Pitt, J. Chem. Soc., Chem. Commun., 1989, 978 DOI: 10.1039/C39890000978
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