The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.
N. Chida, M. Ohtsuka, K. Nakazawa and S. Ogawa, J. Chem. Soc., Chem. Commun., 1989, 436 DOI: 10.1039/C39890000436
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