Site specific gas-phase protonation of 2-t-butylmaleates and 2-t-butylsuccinates upon chemical ionization: stereochemical effects and kinetic control

Abstract

An intense effects of steric hindrance on gas-phase protonation under chemical ionization (Cl) conditions, reflected by a very high site specificity in chemical ionization mass spectrometry (CIMS) of isomeric ethyl methyl esters of 2-t-butylmaleic and 2-t-butylsuccinic acids, provides new direct evidence of kinetic control in the protonation process.