Issue 5, 1989

Enzymatic preparation of optically active bicyclo[2.2.1]heptene derivatives, building blocks for terpenoid natural products. An attractive alternative to enantioselective Diels–Alder syntheses

Abstract

Bicyclo[2.2.1]heptene derivatives (1)–(3), building blocks for terpenoid natural products, have been prepared with high enantiometric purities by enzymatic hydrolysis of their racemic esters in the presence of porcine liver esterase (PLE) and an ester hydrolase from Pseudomonas sp. (SAM-II).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1989, 306-308

Enzymatic preparation of optically active bicyclo[2.2.1]heptene derivatives, building blocks for terpenoid natural products. An attractive alternative to enantioselective Diels–Alder syntheses

J. Van der Eycken, M. Vandewalle, G. Heinemann, K. Laumen, M. P. Schneider, J. Kredel and J. Sauer, J. Chem. Soc., Chem. Commun., 1989, 306 DOI: 10.1039/C39890000306

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