Chemically bonded cyclodextrin stationary phase for the high-performance liquid chromatographic separation and determination of sulphonamides

Abstract

Mixtures of seven sulphonamides have been separated successfully on a β-cyclodextrin stationary phase by high-performance liquid chromatography (HPLC) using phosphate buffer (pH 7.0)-methanol (85 + 15). The HPLC determination of trisulphapyrimidines and Polysulpha in dosage forms is described. That the proposed method is accurate was established from the percentage recoveries of standard sulphonamide solutions.