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Issue 9, 1989
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Isoxazolinyldioxepins. Part 1. Structure–reactivity studies of the hydrolysis of oxazolinyldioxepin derivatives

Abstract

The preparation and acid catalysed hydrolysis of a number of isoxazolinyldioxepins is reported. Individual diastereoisomer pairs were isolated by column chromatography and shown to differ significantly in their hydrolytic stability at acidic pH. The crystal structures of one diastereoisomer pair reveal that conformational differences induce a selective stereoelectronic effect at the acetal centre of the more hydrolytically labile isomer, while the less labile isomer shows no such selectivity.

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Article type: Paper
DOI: 10.1039/P29890001265
J. Chem. Soc., Perkin Trans. 2, 1989, 1265-1269

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    Isoxazolinyldioxepins. Part 1. Structure–reactivity studies of the hydrolysis of oxazolinyldioxepin derivatives

    P. Camilleri, D. Munro, K. Weaver, D. J. Williams, H. S. Rzepa and A. M. Z. Slawin, J. Chem. Soc., Perkin Trans. 2, 1989, 1265
    DOI: 10.1039/P29890001265

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