Issue 21, 1989

Enantiocontrolled synthesis of (+)-aphanorphine from (R)-O-benzylglycidol: assignment of absolute configuration

Abstract

Aphanorphine, a novel 3-benzazepine alkaloid isolated from the freshwater blue–green alga Aphanizomenon flos-aquae, has been synthesized in the antipodal forms starting from (R)-O-benzylglycidol to establish the absolute configuration of the natural product as (1R, 4R).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1989, 1591-1592

Enantiocontrolled synthesis of (+)-aphanorphine from (R)-O-benzylglycidol: assignment of absolute configuration

S. Takano, K. Inomata, T. Sato and K. Ogasawara, J. Chem. Soc., Chem. Commun., 1989, 1591 DOI: 10.1039/C39890001591

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