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Issue 14, 1989
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Formation of a novel bicyclic γ-lactam with isopenicillin N synthase

Abstract

Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5-carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.

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Article information


J. Chem. Soc., Chem. Commun., 1989, 970-972
Article type
Paper

Formation of a novel bicyclic γ-lactam with isopenicillin N synthase

J. E. Baldwin, J. M. Blackburn, M. Sako and C. J. Schofield, J. Chem. Soc., Chem. Commun., 1989, 970
DOI: 10.1039/C39890000970

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