Synthesis of carbocyclic nucleosides: preparation of (–)-5′-homoaristeromycin and analogues
Abstract
Optically pure 5′-homoaristeromycin has been prepared from (L)-ribonolactone using an intramolecular radical cyclisation process to form the five-membered carbocyclic ring with subsequent displacement of a triflate group using a substituted purine to introduce the base moiety.