Incorporation of labelled racemic 2′-bromonor-reticuline (5) and 2′-nitronor-reticuline (6) into 2′-bromopapaverine (2) and 2′-nitropapaverine (3), respectively, has been studied in Papaver somniferum(Papaveraceae) plants, and specific incorporation of (5) and (6) into (2) and (3), respectively, has been demonstrated. Further, it has been shown that (5) and (6) are not metabolized by the plants to form papaverine (1).
D. S. Bhakuni and S. Jain, J. Chem. Soc., Perkin Trans. 1, 1988, 1929 DOI: 10.1039/P19880001929
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