Synthesis of 5,9,9-trisubstituted 1-azabicyclo[3.3.1]nonanes and their conformational analyses
Abstract
A new route for the preparation of 1-azabicyclo[3.3.1]nonane (1) and related compounds, consisting of the reactions similar to the skeletal rearrangement of 2,3,5,6,7,7a-hexahydro-7a-trichloromethylpyrrolizine (2) into 5,9,9-trichloro-1-azabicyclo[3.3.1]nonane (3), is described. The conformational analysis and some chemical properties of the products are also mentioned.