A novel route to the des-A corticosteroids
Abstract
A novel and efficient synthesis of trans-2,3,3a,4,5,9b-hexahydro-3α-hydroxy-3β-(2-hydroxyacetyl)-7-methoxy-3aβ-methyl-1H-benz[e]indene (10) starting from trans-2,3,3a,4,5,9b-hexahydro-3β-isopropenyl-7-methoxy-3α-methoxymethoxy-3aβ-methyl-1H-benz[e]indene (5) and its conversion into 2′,2′,3a-trimethyl-7-oxo-2,3,3a,4,5,6,7,8,9,9b-decahydro-1H-benz[e]indene-3-spiro-4′-(1,3-dioxan)-5′-yl acetate (14) are described.