Convenient synthesis of mixed anhydrides by the ozonolysis of oxazoles
Abstract
The ozonolysis of azoles was investigated, and the products formed via a 1,2-addition of ozone were the main ones obtained. In particular, 2,5-disubstituted oxazoles (2) were treated with an excess of an ozone–oxygen stream to give the corresponding acid anhydrides (6) quantitatively. This reaction should be useful for the preparation of the mixed anhydrides (6) in good yield at low temperature.
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