2′-Deoxy-2′-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2′-fluoro substituent into a carbocyclic nucleoside
Abstract
Aristeromycin has been converted in four stages into its 2′-deoxy-2′-fluoro-ara-analogue (4); compound (4) displayed potent anti-herpes activity both in vitro and in vivo.