Stereoselective synthesis of pyrrolizidine alkaloids, (+)-heliotridine and (+)-retronecine, by means of an intermolecular carbenoid displacement reaction
Abstract
The stereoselective synthesis of the pyrrolizidine alkaloids (+)-heliotridine and (+)-retronecine from (S)-malic acid has been achieved by employing an intermolecular carbenoid displacement reaction as a key step.