A novel stereospecific synthesis of 5-amino-1-β-D-fructofuranosylimidazole-4-carboxamide
Abstract
A β-D-fructofuranose fused oxazolidine-2-thione has been isolated as the t-butyldimethylsilyl derivative (6), which when desulphurised and treated with α-amino-α-cyanoacetamide gave the silylated 1-β-D-fructofuranosyl aminoimidazole (2b) which when deblocked with methanolic hydrogen chloride produced 5-amino-β-D-fructofuranosyl-imidazole-4-carboxamide (2a).