Synthetic approach to medium-sized cycloalkanones. A one-pot three-carbon ring expansion of carbocyclic β-keto esters
Abstract
By treatment with ButOK in Me2SO, carbocyclic β-keto-esters (5-,6-, and 7-membered rings) with a 4-oxopentyl function at the α-position afforded three-carbon ring expansion products (8-, 9-, and 10-membered rings, respectively).