Specific determination of azathioprine in solution by a spectrophotometric method and its application to a tablet assay

Abstract

A previously reported spectrophotometric method for the determination of azathioprine in the presence of 6-mercaptopurine was evaluated for its specificity in the presence of other major degradation products. A three-pronged validity test proves that the method is stability indicating under all pH conditions. The method is simple, rapid, does not require specialised equipment and produces accurate and reliable results.