The thermodynamic proton–ligand stability constants of some p-substituted N-m-chlorophenylbenzohydroxamic acids in dioxane–water

Abstract

The thermodynamic proton–ligand stability constants of p-substituted N-m-chlorophenylbenzohydroxamic acids in aqueous dioxane media are determined at 25 and 35 °C. The thermodynamic parameters are calculated. The pK_a varies linearly with the mol fraction of dioxane. The constants were correlated with the Hammett equation and rate of alkaline hydrolysis. The effect of substitution on the ionization and rate constant is discussed.