2-Bromo-3-methoxycyclohex-2-enone, a new reagent for the α-arylation of lactams
Abstract
We report efficient syntheses of 2-bromo- and 2-chloro-3-methoxycyclohex-2-enone and their use as m-hydroxyphenyl cation synthons for the α-arylation of lactams. The sequence has been used to synthesize the analgesic drug meptazinol.