Thromboxane A2 analogues from 8-oxabicyclo[3.2.1]oct-6-en-3-ones
Abstract
We describe approaches to thromboxane A2 analogues (3), (4), and (32) which contain 2,6-dioxabicyclo[3.2.1]octane and 2,6-dioxatricyclo[3.3.1.03,7]nonane ring systems. Both were derived from 2-substituted 8-oxabicyclo[3.2.1]oct-6-en-3-ones, which were in turn prepared by cycloadditions of suitable oxyallyls and furans.