The Wittig reaction of phosphoranes and phosphonates with the carbonyl function of mono- and bicyclic β-lactams has been studied and the influence of phosphorane and β-lactam reactivities on the outcome of the reaction noted. The utility and general chemistry of the Wittig products from penicillins and clavulanic acid esters is also reported.
M. L. Gilpin, J. B. Harbridge and T. T. Howarth, J. Chem. Soc., Perkin Trans. 1, 1987, 1369 DOI: 10.1039/P19870001369
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