The first complete synthesis of the antibiotic validamycin B as its dodeca-O-acetate is reported; coupling of the epoxide (6) and the partially protected valienamine derivative (14), followed by deprotection, gives the product (1b) which was identified by 1H n.m.r. spectroscopy.
S. Ogawa and Y. Miyamoto, J. Chem. Soc., Chem. Commun., 1987, 1843 DOI: 10.1039/C39870001843
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