The lithiation of 3-chloropropanal diethyl acetal (easily prepared from acrolein) at –78 °C with lithium naphthalenide followed by reaction with various carbonyl compounds, and final oxidation with m-chloroperbenzoic acid leads to γ-substituted butyrolactones.
J. Barluenga, J. R. Fernández and M. Yus, J. Chem. Soc., Chem. Commun., 1987, 1534 DOI: 10.1039/C39870001534
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