Synthesis of 4,5-dihydro-oxazoles immobilized on silica gel
Abstract
4,5-Dihydro-oxazole (1) has been anchored to silica gel, affording immobilized species that, in comparison with similar systems bound to polystyrene matrices, readily undergo hydrolytic cleavage of the oxazoline ring to give the supported amino alcohol and the free soluble carboxylic acid.