Issue 15, 1987

Norcoclaurine as biosynthetic precursor of thebaine and morphine

Abstract

(R,S)-[1-13C]Norcoclaurine and (R,S)-[1-13C]coclaurine fed to Papaver somniferum plants afford highly enriched thebaine and morphine which are specifically labelled at position C-9; the results are interpreted as showing that the morphine skeleton is built up from the condensation product of dopamine with 4-hydroxyphenylacetaldehyde.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1987, 1160-1162

Norcoclaurine as biosynthetic precursor of thebaine and morphine

S. Loeffler, R. Stadler, N. Nagakura and M. H. Zenk, J. Chem. Soc., Chem. Commun., 1987, 1160 DOI: 10.1039/C39870001160

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