A new synthetic route to (11S)- and (11R)-[11-3H1]porphobilinogen (PBG) is described and the configurations of the products are assigned by degradation to (2S)- and (2R)-[2-3H1]glycollic acids; these PBG samples are used to establish that hydroxymethylbilane synthase converts PBG into the hydroxymethylbilane with overall retention of configuration at the HOCH2– group.
J. Schauder, S. Jendrezejewski, A. Abell, G. J. Hart and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1987, 436 DOI: 10.1039/C39870000436
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