A short and practical synthesis of (2S,5S)-bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine
Abstract
D -Mannitol ahs been converted by five sequential reactions (benzyldenation, trifluoromethanesulphonation, hydrazinolysis, hydrogenolysis, and deacetalisation) into (2S,5S)-bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine.