Issue 12, 1986

Reaction between lithium aluminium hydride and some amino alcohols studied by 27Al and 7Li nuclear magnetic resonance

Abstract

LiAlH4 has been titrated with (–)-N-methylephedrine (1), (–)-quinine (2), and (–)-(S)-4-anilino-3-methylaminobutan-1-ol (3) in tetrahydrofuran and in bis-(2-methoxyethyl) ether. The titrations were followed by 27Al n.m.r. The establishment of equilibrium was verified from the results of back titrations. The ion AlH4 was found to be present in solution when 1.5 mol equiv. of (1) or 1.2 mol equiv. of (2) had been added. Computer fittings to experimental n.m.r. data indicated that disproportionation of monoalkoxyaluminates derived from (1) and (2) with re-formation of LiAlH4 takes place in both solvents. No sign of disproportionation was evident in the case of (3). 7Li N.m.r. showed that the compounds derived from LiAlH4 and the substrates (1)–(3) complex Li+ strongly enough to cause slow exchange on the n.m.r. timescale.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1986, 1899-1903

Reaction between lithium aluminium hydride and some amino alcohols studied by 27Al and 7Li nuclear magnetic resonance

A. Malmvik, U. Obenius and U. Henriksson, J. Chem. Soc., Perkin Trans. 2, 1986, 1899 DOI: 10.1039/P29860001899

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements