Structure and conformation of bioconversion products of a carboxylic ionophorous antibiotic, grisorixin, by means of two-dimensional nuclear magnetic resonance

Abstract

The structures of two bioconversion products of a carboxylic ionophorous antibiotic, grisorixin, have been determined by means of two-dimensional n.m.r. The potassium salt conformations of grisorixin and its bioconversion products are very similar. Grisorixin metabolites still complex the cations, but no longer transport them, and have no antibiotic activity.