Synthesis of (15RS)-11-deoxy-11-oxacarbacyclin methyl ester
Abstract
(1R,2S,5S)-2-Diphenyl-t-butylsiloxymethyl-3-oxabicyclo[3.3.0]octan-7-one (3), prepared from D-ribonolactone, has been converted in six steps into the biologically active prostacyclin analogue (15RS)-11-deoxy-11-oxacarbacyclin methyl ester (2; X = O).