The synthesis of two selectively protected bifunctional analogues of ethylenediaminetetra-acetic acid (EDTA) is described. In these analogues the four carboxy groups involved in chelation are protected as benzyl or t-butyl esters, while the fifth one, which is free, allows their coupling in a predetermined position to a nucleophilic group. An example of their use in solid phase peptide synthesis is given.
C. Sergheraert, P. Mäes and A. Tartar, J. Chem. Soc., Perkin Trans. 1, 1986, 1061 DOI: 10.1039/P19860001061
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