Syntheses of optically active compounds possessing a trifluoromethyl group, via enzymatic chiral Michael addition reaction of 2-(trifluoromethyl)propenoic acid and synthesis of trifluoromethylated heterocycles, have been under-taken.
T. Kitazume, T. Ikeya and K. Murata, J. Chem. Soc., Chem. Commun., 1986, 1331 DOI: 10.1039/C39860001331
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