Synthesis of pyrrolizidine alkaloids, (±)-trachelanthamidine, (±)-isoretronecanol, and (±)-supinidine, by means of an intramolecular carbenoid displacement (ICD) reaction
Abstract
The syntheses of pyrrolizidine alkaloids, (±)-trachelanthamidine, (±)-isoretronecanol, and (±)-supinidine were achieved via a carbon–carbon bond formation at the α-position to the nitrogen by employing an intramolecular carbenoid displacement (ICD) reaction as a key step.