The reactions of α-monosubstituted primary amines with 1,4-dimethyl-6-hydroxycarbazole and 9-hydroxyellipticine under oxidative conditions: formation of a novel series of annulated oxazoles

Abstract

The oxidative nucleophilic addition reactions of α-monosubstituted primary amines (RCH₂NH₂) with a 5-hydroxyindole-containing molecular framework such as 1,4-dimethyl-6-hydroxycarbazole and 9-hydroxyelli-pticine in the presence of manganese dioxide led to the formation of a new series of annulated oxazoles (6)–(11).