A series of unsaturated tripeptides have been synthesised and evaluated as substrates for isopenicillin N synthetase; variations in the C-terminal amino acid have led to a structure reactivity profile which indicates a stereochemical dependence on the balance between desaturative vs. hydroxylative ring closures.
J. E. Baldwin, R. M. Adlington, A. Basak, S. L. Flitsch, A. K. Forrest and H. Ting, J. Chem. Soc., Chem. Commun., 1986, 273 DOI: 10.1039/C39860000273
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