Spectrophotometric determination of some pharmaceutical carbonyl compounds through oximation and subsequent charge-transfer complexation reactions

Abstract

Two spectrophotometric procedures are presented for the determination of six pharmaceutical carbonyl compounds through charge-transfer complexation of their oximes with either the σ-acceptor iodine or the π-acceptor choranil. The optimum assay conditions and their applicability to the determination of the test compounds in pharmaceutical products are described. The results obtained, which compared favourably with those given by a pharmacopoeial method, illustrate the accuracy, sensitivity and simplicity of the developed procedures.