Jump to main content
Jump to site search

Issue 2, 1986
Previous Article Next Article

Interaction of metal ions with 2′-deoxyribonucleotides. Crystal and molecular structure of a cobalt(II) complex with 2′-deoxyinosine 5′-monophosphate

Abstract

The crystal structure of the cobalt(II) complex with 2′-deoxyinosine 5′-monophosphate (5′-dlMP), [Co(5′-dlMP)(H2O)5]·2H2O, has been analysed by X-ray diffraction. The complex crystallizes in the space group P212121 with a= 6.877(3), b= 10.904(2), c= 25.421(6)Å, and Z= 4. The structure was solved by the heavy-atom method and refined to an R value of 0.043 using 1 776 unique reflections. The cobalt ion binds only to the 6-oxopurine base of the nucleotide at the N(7) position, the octahedral co-ordination of the metal being completed by five water oxygens. The phosphate oxygens are involved in hydrogen bonding with the co-ordinated water molecules. The structure is closely similar to that of the corresponding ribonucleotide complex. The nucleotide has the energetically preferred conformation: an anti base, a C(3′)-endo sugar pucker, and a gauchegauche conformation about the C(4′)–C(5′) bond. The significance of sugar puckering in the monomeric complexes of general formula [M(5′-nucleotide)(H2O)5] is explained in terms of the structural requirements for metal–water–phosphate bridging interactions.

Back to tab navigation

Article type: Paper
DOI: 10.1039/DT9860000309
J. Chem. Soc., Dalton Trans., 1986, 309-312

  •   Request permissions

    Interaction of metal ions with 2′-deoxyribonucleotides. Crystal and molecular structure of a cobalt(II) complex with 2′-deoxyinosine 5′-monophosphate

    M. D. Poojary and H. Manohar, J. Chem. Soc., Dalton Trans., 1986, 309
    DOI: 10.1039/DT9860000309

Search articles by author

Spotlight

Advertisements