Chiral synthesis of 3-substituted morpholines via serine enantiomers and reductions of 5-oxomorpholine-3-carboxylates
Abstract
The chiral synthesis of 3-hydroxymethyl- and 3-carboxy-morpholines from serine enantiomers is described. Chemoselective and total reductions of 5-oxomorpholine-3-carboxylates are key synthetic steps.