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Issue 0, 1985
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Convenient synthesis of stereospecifically deuteriated glycines from glutamic acid using a combination of enzymatic and chemical methods

Abstract

Chiral glycines (1a) and (1b) have been synthesized starting from stereospecifically deuteriated 4-aminobutanoic acids (3a) and (3b). Enzymatic decarboxylation of (2S)-glutamic acid (2a) in 2H2O and (2R,S)-[2,4,4-2H3]glutamic acid (2b)+(2c) in H2O afforded (3a) and (3b), respectively. Chemical transformations of deuteriated pyrrolidinones (4a) and (4b) afforded stereospecifically labelled glycines (1a) and (1b) in good yields.

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Article type: Paper
DOI: 10.1039/P19850002389
J. Chem. Soc., Perkin Trans. 1, 1985, 2389-2392

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    Convenient synthesis of stereospecifically deuteriated glycines from glutamic acid using a combination of enzymatic and chemical methods

    E. Santaniello, R. Casati and A. Manzocchi, J. Chem. Soc., Perkin Trans. 1, 1985, 2389
    DOI: 10.1039/P19850002389

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