Peptide synthesis. Part 6. Protection of the sulphydryl group of cysteine in solid-phase synthesis using Nα-fluorenylmethoxycarbonylamino acids. Linear oxytocin derivatives
Abstract
The Nα-fluorenylmethoxycarbonyl derivatives of S-acetamidomethyl-, S-t-butyl-, and S–S–t-butylcysteine have been prepared and used in solid-phase peptide synthesis on polar, poly(dimethylacrylamide) supports. All three derivatives proved suitable as judged by synthesis of the linear oxytocin nonapeptide amide sequence.