Effects of surface heterogeneity on liquid adsorption chromatography with mixed mobile phases. Analytical approximations for partition coefficients

Abstract

The effects of the energetic heterogeneity of solid/solution interfaces on the behaviour of liquid–solid chromatography systems have been investigated theoretically and the existing theories have been re-examined. This has led to a more rigorous explanation of the theoretical background of some equations which were developed in a semi-intuitive manner. In other cases, e.g. Soczewiński's logarithmic relationship, a totally new theoretical interpretation has been obtained explaining why the tangent of this linear relationship is < 1 in many cases.