The synthesis of potential anticancer and antitumour nucleosides, 2′-deoxy-5-monofluoromethyluridine (FTDR) and 2′-deoxy-5-difluoromethyluridine (F2TDR) was achieved in four steps from thymidine including monosilylation with t-butyldiphenylsilyl chioride, photochemical brominatio, followed by AgF treatment and subsequent desilylation.
J. Matulic-Adamic and K. A. Watanabe, J. Chem. Soc., Chem. Commun., 1985, 1535 DOI: 10.1039/C39850001535
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