Total synthesis of optically active 17β-t-butoxy-3-methoxy-7α- or -7β-18-dimethyl-1,3,5(10)-estratriene
Abstract
In the preparation of 7-methyl-19-nor-steroids, a new method for the synthesis of key intermediates (10), which involves alkylation of the CD ring fragment (4) and subsequent hydrogenation, cyclization, and hydrogenation is described.