Stereoselective synthesis of (+)-strictanonic acid, the enantiomer of a new type of diterpenoid, isolated from Grindelia stricta and Chrysothamnus paniculatus
Abstract
The synthesis of (+)-strictanonic acid (1a) from grindelic acid (2a)via the key intermediate (3a) is described; the synthesis confirms the proposed structure of (1a) and establishes its absolute stereochemistry.