A study of the biosynthesis of the polyketide polivione in Penicillium frequentans, using 13C-, 2H-, and 18O-labelled precursors
Abstract
Polivione, a polyketide metabolite of Penicillium frequentans is shown to incorporate 13C-, 2H-, and 18O-labelled acetates, and 18O-labelled oxygen gas, in a manner consistent with a biosynthesis via a naphthalene intermediate having the same carbon skeleton as fusarubin.